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A histological examination allowed to diagnose melanoma and distant metastases in brain and heart. Moreover, there were multiple brain metastases (up to 1.5 cm) in both hemispheres. The autopsy revealed, isolated cardiac metastasis in the right atrium and left ventricle. The patient's condition has progressively worsened, and on the fourth day, the patient died of heart failure. In the course of a clinical examination, a tumour was discovered in the parietal lobe on the right hemisphere (1.6x2.5 cm) and a pigmented lesion on the right foot of the patient (5x3 cm). was admitted to the hospital in a severe condition. Extensive intramural metastases were found in the myocardium. Histologically, the tumour included glandular structures with foci of massive necrosis. An autopsy revealed a tumour in the lower third of the oesophagus, which spread to the cardiac compartment of the stomach, diaphragm, pericardium, epicardium, and myocardium of a right ventricle. Results: First case: a 79-years-old patient with cardiooesophageal cancer, died in the clinic with an increasing heart failure. Furthermore, we detected the presence of sequences of Trypanosoma cruzi, Leishmania donovani and antibiotic-resistance genes. Bacterial groups present in the mummies included the Bacillales, Enterobacteriales and, especially, the Clostridiales it is feasible to hypothesize that these individuals were exposed to these pathogens by the ingestion of contaminated food and water. DNA was extracted and the shotgun metagenomic sequencing showed bacterial and fungal taxa that may resemble both the thanatomicrobiome and extant human gut microbiomes. Amastigotes of Trypanosoma cruzi were clearly detected in the myocardial fibers. The other corpse presented a marked megavisceral syndrome characterized by megacolon, megaoesophagus and cardiomegaly. Results: Histopathological study on the tissue specimens of the lungs of the first mummy showed numerous alveoli, in large fibrous stroma, areas of pulmonary anthracosis and a massive presence of alveolar exudate compatible with the diagnosis of bronchopneumonia. Stains for thrombomodulin, heparanase-2, CD34, and glycocalyx did not seem to mirror these morphological differences hitherto. gemcitabine revealed more glomerular and overall thrombi). arteriolar/hilar involvement), humoral transplant rejection and toxic injury (e.g. Grouping of clinically well-characterized patients regarding the underlying cause for TMA showed differences between morphological criteria comparing genetically verified atypical HUS (e.g. Detailed ultrastructural comparison between TMA combined with humoral rejection and humoral rejection alone could not define any differences between these two groups. Most useful histological TMA criteria were fragmented red blood cells (glomerular 65%, arterioles/arteries 67%), fibrillar appearance of mesangium (66%), endothelial swelling (glomeruli 68%, arterioles 67%), thickened capillary walls (66%), collapse of capillary tuft (92%) and arterial intimal mucoid edema (arteries 78%, arterioles 47%). Thrombi were identified in 71% of KTx TMA cases (glomerular 41%, arteriolar 40%, arteries 25%) compared to 67% of native kidneys (glomerular 38%, arteriolar 53%, arteries 41%).
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45% of TMA cases occured in kidney transplants (KTx), 53% of these had rejection (cellular 7%, humoral 34%, mixed 12%). Results: TMA patients’ (female 45%) age ranged from 4 to 81 years. KIAA1429/YTHDF3 were differentially expressed among individual TGCT components, both at mRNA and immunohistochemistry levels. Patients with strong m6A immunoexpression showed significantly higher KIAA1429 mRNA expression levels and stronger KIAA1429 immunostaining (p<0.001, p<0.01), indicating an association between the writer and the established RNA modification (m6A). KIAA1429 immunostaining also discriminated SEvsNST(p<0.01).
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Immunohistochemistry reproduced transcript findings, with patients showing strong KIAA1429 immunoexpression exhibiting higher mRNA expression levels(p<0.001). A moderate correlation was found between expression levels of KIAA1429 and YTHDF3(correlation coefficient 0.44). Stage I patients had higher YTHDF3 expression(p=0.04). KIAA1429 showed the best performance, discriminating SEvsNST with AUC=0.85(sensitivity 77.3%, specificity 81.1%, PPV 71.6%, NPV 85.3%, Accuracy 79.7%). Results: There were significant differences in KIAA1429/YTHDF3 mRNA expression levels among tumour subtypes, with Seminomas (SEs) exhibiting higher levels than Non-Seminomatous tumours (NSTs) (p<0.01, p<0.01).